Driclor and Anhydrol Forte can be used for treating hand sweating, and are the first thing to try. Do read instructions carefully.
Although Botulinum will work in the hands, there are several reasons why it is not a good idea. The hand is very sensitive and because of the large number of injections needed to cover it is very painful. In addition, the muscles are close to the skin, and there is a risk that they may become affected by the toxin, leading to weakness in the hand.
ETS is 99% effective at curing hand sweating – palmar hyperhidrosis. The effect is permanent. It is also 80% effective at curing armpit sweating – axillary hyperhidrosis – when done at the same time. However, ETS is a fairly major operation and, like all operations, has a risk of side-effects and complications. Still, if iontophoresis is not an option, and the sweating is very severe, ETS can be life changing. ETS is performed by vascular surgeons – your GP could refer you to one.